Sibiromycin: isolation and characterization.

نویسندگان

M G Brazhnikova

N V Konstantinova

A S Mesentsev

چکیده

Sibiromycin, possessing strong antitumor activity in animal experiments, is produced by Streptosporangium sibiricum. Sibiromycin can be isolated from culture filtrate using ion-exchange or by solvent extraction. The antibiotic was obtained as a crystalline substance with ultraviolet absorption maximaat 230 and 310 nm, [a]D+525° (in dimethylformamide); the empirical formula-C24H31N3O7. In 1 N hydrochloric acid, sibiromycin is transformed into "the product of acidic inactivation" (PAI), C24H29N3O6. Hydrolysis of PAI with 6nHCI affords "the product of acidic hydrolysis" (PAH), C16H14N2O3. Methanolysis of sibiromycin and PAI yields the methylglycoside of a new amino sugar sibirosamine, C8H16NO3 (OCH8). Aqueous alkaline hydrolysis of PAI and PAH affords the crystalline substance C8H9NO.

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